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A slight drop in hospital admissions after amyloid PET, especially in people with positive scans, fell well short of the prespecified endpoint. Still, IDEAS is broadening into a research platform, and IDEAS 2 will add racial diversity.

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New genetic variants emerged by harmonizing whole-exome-sequencing data across continents, and by using imputation to plumb the depths of existing GWAS. One variant encodes a microglial phospholipid transporter.

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In large population datasets, people who had been vaccinated against influenza or pneumonia appeared less likely to develop AD.

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This early marker distinguishes Alzheimer’s from controls and other neurodegenerative diseases more accurately than other biomarkers.

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Poor coordination among grid cells in the entorhinal cortex and place cells in the hippocampus compromises navigation. Grid cells fail first.

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This neuronal protein regulates the complement cascade in the developing brain. Could it do the same in aging or neurodegenerative disease?

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In striatal spiny projection neurons with mutant huntingtin, mitochondria spill immunogenic RNAs into the cytosol. These touch off innate antiviral signaling inside the neurons, which may spell their demise.